Analysis of a pair of END(+) and END(−) viruses derived from the same bovine viral diarrhea virus stock reveals the amino acid determinants in N(pro) responsible for inhibition of type I interferon production

The Exaltation of Newcastle disease virus (END) phenomenon is induced by the inhibition of type I interferon in pestivirus-infected cells in vitro, via proteasomal degradation of cellular interferon regulatory factor (IRF)-3 with the property of the viral autoprotease protein N(pro). Reportedly, the...

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Bibliographische Detailangaben
Veröffentlicht in:J Vet Med Sci
Hauptverfasser: KOZASA, Takashi, ABE, Yuri, MITSUHASHI, Kazuya, TAMURA, Tomokazu, AOKI, Hiroshi, ISHIMARU, Masatoshi, NAKAMURA, Shigeyuki, OKAMATSU, Masatoshi, KIDA, Hiroshi, SAKODA, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Veterinary Science 2014
Schlagworte:
Virology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478729/
https://ncbi.nlm.nih.gov/pubmed/25648277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.14-0420
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