Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm...

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Bibliographic Details
Published in:Nat Mater
Main Authors: Veiseh, Omid, Doloff, Joshua C., Ma, Minglin, Vegas, Arturo J., Tam, Hok Hei, Bader, Andrew R., Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Siebert, Sean, Tang, Katherine, Hollister-Lock, Jennifer, Aresta-Dasilva, Stephanie, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Chen, Michael, Dholakia, Nimit, Thakrar, Raj, Lacík, Igor, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477281/
https://ncbi.nlm.nih.gov/pubmed/25985456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4290
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