Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm...

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Publié dans:Nat Mater
Auteurs principaux: Veiseh, Omid, Doloff, Joshua C., Ma, Minglin, Vegas, Arturo J., Tam, Hok Hei, Bader, Andrew R., Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Siebert, Sean, Tang, Katherine, Hollister-Lock, Jennifer, Aresta-Dasilva, Stephanie, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Chen, Michael, Dholakia, Nimit, Thakrar, Raj, Lacík, Igor, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477281/
https://ncbi.nlm.nih.gov/pubmed/25985456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4290
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