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High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivo

Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent Mycobacterium tuberculosis was examined using resuscitation promoting fa...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Hu, Yanmin, Liu, Alexander, Ortega-Muro, Fatima, Alameda-Martin, Laura, Mitchison, Denis, Coates, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477163/
https://ncbi.nlm.nih.gov/pubmed/26157437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00641
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