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Antibody Drug Conjugates: Application of Quantitative Pharmacology in Modality Design and Target Selection
Antibody drug conjugates (ADCs) are a multi-component modality comprising of an antibody targeting a cell-specific antigen, a potent drug/payload, and a linker that can be processed within cellular compartments to release payload upon internalization. Numerous ADCs are being evaluated in both resear...
Gardado en:
| Publicado en: | AAPS J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476995/ https://ncbi.nlm.nih.gov/pubmed/25933599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9766-0 |
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