Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Effective tuberculosis (TB) vaccine should target tubercle bacilli with various metabolic states and confer long-term protective immunity. In this study, we constructed a novel multi-stage TB subunit vaccine based on fusion protein ESAT6-Ag85B-MPT64(190-198)-Mtb8.4-HspX (LT69 for short) which combin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Niu, Hongxia, Peng, Jinxiu, Bai, Chunxiang, Liu, Xun, Hu, Lina, Luo, Yanping, Wang, Bingxiang, Zhang, Ying, Chen, Jianzhu, Yu, Hongjuan, Xian, Qiaoyang, Zhu, Bingdong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476732/
https://ncbi.nlm.nih.gov/pubmed/26098302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130641
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