Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers, and currently under evaluation in hospitalized infants. Here...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K., Fung, Amy, Stevens, Sarah K., Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D., Serebryany, Vladimir, Liu, Jyanwei, Smith, David B., Tam, Yuen, Zhang, Qingling, Moore, Martin L., Fearns, Rachel, Chanda, Sushmita M., Blatt, Lawrence M., Symons, Julian A., Beigelman, Leo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476725/
https://ncbi.nlm.nih.gov/pubmed/26098424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004995
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