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Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

Sustained agonist-induced production of the second messengers InsP(3) and diacylglycerol requires steady delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER to the plasma membrane (PM) to maintain PtdIns(4,5)P(2) levels. Similarly, phosphatidic acid (PtdOH), generated from...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Kim, Yeun Ju, Guzman-Hernandez, Maria-Luisa, Wisniewski, Eva, Balla, Tamas
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476625/
https://ncbi.nlm.nih.gov/pubmed/26028218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.04.028
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