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Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence
Sustained agonist-induced production of the second messengers InsP(3) and diacylglycerol requires steady delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER to the plasma membrane (PM) to maintain PtdIns(4,5)P(2) levels. Similarly, phosphatidic acid (PtdOH), generated from...
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| Udgivet i: | Dev Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476625/ https://ncbi.nlm.nih.gov/pubmed/26028218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.04.028 |
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