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Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment

Motivated by applications to confirmatory clinical trials for testing a new treatment against a placebo or active control when the new treatment has k possible treatment strategies (arms)—for example, k possible doses for a new drug—we develop an asymptotic theory for efficient outcome-adaptive rand...

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Detalhes bibliográficos
Publicado no:Seq Anal
Main Authors: Lai, Tze Leung, Liao, Olivia Yueh-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476492/
https://ncbi.nlm.nih.gov/pubmed/26109746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07474946.2012.719433
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