Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models

We explore the prediction of individuals' phenotypes for complex traits using genomic data. We compare several widely used prediction models, including Ridge Regression, LASSO and Elastic Nets estimated from cohort data, and polygenic risk scores constructed using published summary statistics f...

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Detalles Bibliográficos
Publicado en:Hum Mol Genet
Main Authors: Spiliopoulou, Athina, Nagy, Reka, Bermingham, Mairead L., Huffman, Jennifer E., Hayward, Caroline, Vitart, Veronique, Rudan, Igor, Campbell, Harry, Wright, Alan F., Wilson, James F., Pong-Wong, Ricardo, Agakov, Felix, Navarro, Pau, Haley, Chris S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Association Studies Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476450/
https://ncbi.nlm.nih.gov/pubmed/25918167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv145
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