The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits

Genome-wide association studies (GWAS) have provided valuable insights into the genetic basis of complex traits. However, they have explained relatively little trait heritability. Recently, we proposed a new analytical approach called regional heritability mapping (RHM) that captures more of the mis...

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Detalhes bibliográficos
Main Authors: Uemoto, Yoshinobu, Pong-Wong, Ricardo, Navarro, Pau, Vitart, Veronique, Hayward, Caroline, Wilson, James F., Rudan, Igor, Campbell, Harry, Hastie, Nicholas D., Wright, Alan F., Haley, Chris S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832942/
https://ncbi.nlm.nih.gov/pubmed/24312116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00232
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