Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

The molecular bases of myelodysplastic syndromes (MDS) are not fully understood. Trimethylated histone 4 lysine 3 (H3K4me3) is present in promoters of actively transcribed genes and has been shown to be involved in hematopoietic differentiation. We performed a genome-wide H3K4me3 CHIP-Seq analysis o...

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Pubblicato in:Leukemia
Autori principali: Wei, Yue, Chen, Rui, Dimicoli, Sophie, Bueso-Ramos, Carlos, Neuberg, Donna, Pierce, Sherry, Wang, Hui, Yang, Hui, Jia, Yu, Zheng, Hong, Fang, Zhihong, Nguyen, Martin, Ganan-Gomez, Irene, Ebert, Benjamin, Levine, Ross, Kantarjian, Hagop, Garcia-Manero, Guillermo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476310/
https://ncbi.nlm.nih.gov/pubmed/23538751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.91
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