Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats

BACKGROUND: Dynorphin, an endogenous ligand at kappa opioid receptors (KOR), produces depressive-like effects and contributes to addictive behavior in male non-human primates and rodents. Although comorbidity of depression and addiction is greater in women than men, the role of KORs in female motiva...

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Gepubliceerd in:Biol Psychiatry
Hoofdauteurs: Russell, Shayla E., Rachlin, Anna B., Smith, Karen L., Muschamp, John, Berry, Loren, Zhao, Zhiyang, Chartoff, Elena H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476271/
https://ncbi.nlm.nih.gov/pubmed/24090794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.07.042
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