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Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization
PURPOSE: Amphotericin B (AmB) is an effective anti-fungal and anti-leishmanial agent. However, AmB has low oral bioavailability (0.3%) and adverse effects (e.g., nephrotoxicity). The objectives of this study were to improve the oral bioavailability by entrapping AmB in pegylated (PEG) poly lactide c...
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| Publicado no: | Saudi Pharm J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4475820/ https://ncbi.nlm.nih.gov/pubmed/26106277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2014.11.004 |
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