Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep

Prenatal T excess induces maternal hyperinsulinemia, early puberty, and reproductive/metabolic defects in the female similar to those seen in women with polycystic ovary syndrome. This study addressed the organizational/activational role of androgens and insulin in programming pubertal advancement a...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Padmanabhan, Vasantha, Veiga-Lopez, Almudena, Herkimer, Carol, Abi Salloum, Bachir, Moeller, Jacob, Beckett, Evan, Sreedharan, Rohit
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475717/
https://ncbi.nlm.nih.gov/pubmed/25919188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1235
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