A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

INTRODUCTION: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and has been linked to various cancers. Cellular microvesicle (MV) release, which...

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Detalles Bibliográficos
Publicado en:J Extracell Vesicles
Autores principales: Kholia, Sharad, Jorfi, Samireh, Thompson, Paul R., Causey, Corey P., Nicholas, Anthony P., Inal, Jameel M., Lange, Sigrun
Formato: Artigo
Lenguaje:Inglês
Publicado: Co-Action Publishing 2015
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Original Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475687/
https://ncbi.nlm.nih.gov/pubmed/26095379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/jev.v4.26192
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