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N(6)-methyl-adenosine (m6A) marks primary microRNAs for processing

The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA binding protein DGCR8 and the ribonuclease type III DROSHA(1–4). This initial event requires the recognition of the junction between the stem and the f...

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Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Alarcón, Claudio R., Lee, Hyeseung, Goodarzi, Hani, Halberg, Nils, Tavazoie, Sohail F.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475635/
https://ncbi.nlm.nih.gov/pubmed/25799998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14281
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