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Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State

Envelope glycoprotein gp120 of HIV-1 possesses several variable regions whose precise structure has been difficult to establish. We report a new model of gp120, in complex with antibodies CD4 and 17b, complete with its variable regions. The model was produced by a computational protocol which uses c...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Rasheed, Muhibur, Bettadapura, Radhakrishna, Bajaj, Chandrajit
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474864/
https://ncbi.nlm.nih.gov/pubmed/26039348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.03.026
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