Epigenetic Activity of Peroxisome Proliferator-Activated Receptor Gamma Agonists Increases the Anticancer Effect of Histone Deacetylase Inhibitors on Multiple Myeloma Cells

Epigenetic modifications play a major role in the development of multiple myeloma. We have previously reported that the PPARγ agonist pioglitazone (PIO) enhances, in-vitro, the cytotoxic effect of the Histone deacetylase inhibitor (HDACi), valproic acid (VPA), on multiple myeloma cells. Here, we des...

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Udgivet i:PLoS One
Main Authors: Aouali, Nassera, Broukou, Angeliki, Bosseler, Manon, Keunen, Olivier, Schlesser, Vincent, Janji, Bassam, Palissot, Valerie, Stordeur, Philippe, Berchem, Guy
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474836/
https://ncbi.nlm.nih.gov/pubmed/26091518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130339
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