Interleukin-10 Enhances the Intestinal Epithelial Barrier in the Presence of Corticosteroids through p38 MAPK Activity in Caco-2 Monolayers: A Possible Mechanism for Steroid Responsiveness in Ulcerative Colitis

Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocortico...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lorén, Violeta, Cabré, Eduard, Ojanguren, Isabel, Domènech, Eugeni, Pedrosa, Elisabet, García-Jaraquemada, Arce, Mañosa, Miriam, Manyé, Josep
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474693/
https://ncbi.nlm.nih.gov/pubmed/26090671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130921
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