Conditional U1 Gene Silencing in Toxoplasma gondii

The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing. U1 snRNP is critical in pre-mRNA splicing by defini...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pieperhoff, Manuela S., Pall, Gurman S., Jiménez-Ruiz, Elena, Das, Sujaan, Melatti, Carmen, Gow, Matthew, Wong, Eleanor H., Heng, Joanne, Müller, Sylke, Blackman, Michael J., Meissner, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474610/
https://ncbi.nlm.nih.gov/pubmed/26090798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130356
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