DNA Damage Regulates Translation through β-TRCP Targeting of CReP

The Skp1-Cul1-F box complex (SCF) associates with any one of a number of F box proteins, which serve as substrate binding adaptors. The human F box protein βTRCP directs the conjugation of ubiquitin to a variety of substrate proteins, leading to the destruction of the substrate by the proteasome. To...

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Udgivet i:PLoS Genet
Main Authors: Loveless, Theresa B., Topacio, Benjamin R., Vashisht, Ajay A., Galaang, Shastyn, Ulrich, Katie M., Young, Brian D., Wohlschlegel, James A., Toczyski, David P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474599/
https://ncbi.nlm.nih.gov/pubmed/26091241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005292
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