Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells

BACKGROUND: DNA methylation patterns are initiated by de novo DNA methyltransferases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of early embryos. These patterns are faithfully maintained by DNMT1 during DNA replication to ensure epigenetic inheritance across gene...

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Udgivet i:Genome Biol
Main Authors: Li, Zhiguang, Dai, Hongzheng, Martos, Suzanne N., Xu, Beisi, Gao, Yang, Li, Teng, Zhu, Guangjing, Schones, Dustin E., Wang, Zhibin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474455/
https://ncbi.nlm.nih.gov/pubmed/26032981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0685-2
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