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Sculpting the Immunological Response to Dengue Fever by Polytopic Vaccination
The twin challenges of immunodominance and heterologous immunity have hampered discovery of an effective vaccine against all four dengue viruses. Here we explore how the T cell competition and selection underlying these asymmetrical properties impede effective T cell vaccine design. The theory we de...
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| Published in: | Vaccine |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4474404/ https://ncbi.nlm.nih.gov/pubmed/16417956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2005.12.031 |
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