DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status

INTRODUCTION: Isocitrate dehydrogenase (IDH) mutation status and grade define subgroups of diffuse gliomas differing based on age, tumor location, presentation, and prognosis. While some biologic differences between IDH mutated (IDH(mut)) and wild-type (IDH(wt)) gliomas are clear, the distinct alter...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Cohen, Adam, Sato, Mariko, Aldape, Kenneth, Mason, Clinton C., Alfaro-Munoz, Kristin, Heathcock, Lindsey, South, Sarah T., Abegglen, Lisa M., Schiffman, Joshua D., Colman, Howard
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474351/
https://ncbi.nlm.nih.gov/pubmed/26091668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0213-3
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