Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

An effective human immunodeficiency virus type 1 (HIV-1) vaccine must induce protective antibody responses, as well as CD4(+) and CD8(+) T cell responses, that can be effective despite extraordinary diversity of HIV-1. The consensus and mosaic immunogens are complete but artificial proteins, computa...

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Publicado en:J Virol
Main Authors: Hulot, Sandrine L., Korber, Bette, Giorgi, Elena E., Vandergrift, Nathan, Saunders, Kevin O., Balachandran, Harikrishnan, Mach, Linh V., Lifton, Michelle A., Pantaleo, Giuseppe, Tartaglia, Jim, Phogat, Sanjay, Jacobs, Bertram, Kibler, Karen, Perdiguero, Beatriz, Gomez, Carmen E., Esteban, Mariano, Rosati, Margherita, Felber, Barbara K., Pavlakis, George N., Parks, Robert, Lloyd, Krissey, Sutherland, Laura, Scearce, Richard, Letvin, Norman L., Seaman, Michael S., Alam, S. Munir, Montefiori, David, Liao, Hua-Xin, Haynes, Barton F., Santra, Sampa
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474309/
https://ncbi.nlm.nih.gov/pubmed/25855741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00383-15
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