The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity

The human JC polyomavirus (JCPyV) establishes an asymptomatic, persistent infection in the kidneys of the majority of the population and is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals. The Mad-1 strain of JCP...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Ströh, Luisa J., Maginnis, Melissa S., Blaum, Bärbel S., Nelson, Christian D. S., Neu, Ursula, Gee, Gretchen V., O'Hara, Bethany A., Motamedi, Nasim, DiMaio, Daniel, Atwood, Walter J., Stehle, Thilo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Structure and Assembly
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474300/
https://ncbi.nlm.nih.gov/pubmed/25855729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00489-15
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