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The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity

The human JC polyomavirus (JCPyV) establishes an asymptomatic, persistent infection in the kidneys of the majority of the population and is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals. The Mad-1 strain of JCP...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Ströh, Luisa J., Maginnis, Melissa S., Blaum, Bärbel S., Nelson, Christian D. S., Neu, Ursula, Gee, Gretchen V., O'Hara, Bethany A., Motamedi, Nasim, DiMaio, Daniel, Atwood, Walter J., Stehle, Thilo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474300/
https://ncbi.nlm.nih.gov/pubmed/25855729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00489-15
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