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Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif
The human JC polyomavirus (JCV) causes a fatal demyelinating disease, Progressive Multifocal Leukoencephalopathy (PML), in immunocompromised individuals. Current treatment options for PML are inadequate. Sialylated oligosaccharides and the serotonin receptor are known to be necessary for JCV entry,...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957469/ https://ncbi.nlm.nih.gov/pubmed/20951965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.09.004 |
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