Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity

BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. HYPOTHESIS/OBJECTIVES: We hypothesized that poly...

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Udgivet i:J Vet Intern Med
Main Authors: Funk-Keenan, J., Sacco, J., (Amos) Wong, Y. Y., Rasmussen, S., Motsinger-Reif, A., Trepanier, L. A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474156/
https://ncbi.nlm.nih.gov/pubmed/22816446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1939-1676.2012.00965.x
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