Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity

BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. HYPOTHESIS/OBJECTIVES: We hypothesized that poly...

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Pubblicato in:J Vet Intern Med
Autori principali: Funk-Keenan, J., Sacco, J., (Amos) Wong, Y. Y., Rasmussen, S., Motsinger-Reif, A., Trepanier, L. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474156/
https://ncbi.nlm.nih.gov/pubmed/22816446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1939-1676.2012.00965.x
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