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CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Although cytomegalovirus (CMV) reactivation has long been implicated in posttransplant immune dysfunction, the molecular mechanisms that drive this phenomenon remain undetermined. To address this, we combined multiparameter flow cytometric analysis and T-cell subpopulation sorting with high-throughp...

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Publicado en:Blood
Main Authors: Suessmuth, Yvonne, Mukherjee, Rithun, Watkins, Benjamin, Koura, Divya T., Finstermeier, Knut, Desmarais, Cindy, Stempora, Linda, Horan, John T., Langston, Amelia, Qayed, Muna, Khoury, Hanna J., Grizzle, Audrey, Cheeseman, Jennifer A., Conger, Jason A., Robertson, Jennifer, Garrett, Aneesah, Kirk, Allan D., Waller, Edmund K., Blazar, Bruce R., Mehta, Aneesh K., Robins, Harlan S., Kean, Leslie S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473113/
https://ncbi.nlm.nih.gov/pubmed/25852054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-631853
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