Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells

The direct effect of immunosuppressive drugs calcineurin inhibitor (Tacrolimus, TAC) and mTOR inhibitor (Sirolimus, SRL) on B cell activation, differentiation and proliferation is not well documented. Purified human B cells from healthy volunteers were stimulated through the B Cell Receptor with Ant...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Traitanon, Opas, Mathew, James M, La Monica, Giovanna, Xu, Luting, Mas, Valeria, Gallon, Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472515/
https://ncbi.nlm.nih.gov/pubmed/26087255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129658
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