ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac DRG neurons

RATIONALE: Acid-Sensing Ion Channels (ASICs) are Na(+) channels that are activated by acidic pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes has made them leading candidates to sense cardiac ischemia. OBJECTIVE: Four genes encode six different ASIC subunits,...

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Gepubliceerd in:Circ Res
Hoofdauteurs: Hattori, Tomonori, Chen, Jie, Harding, Anne Marie S., Price, Margaret P., Lu, Yongjun, Abboud, Francois M., Benson, Christopher J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472433/
https://ncbi.nlm.nih.gov/pubmed/19590043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.202036
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