The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

BACKGROUND: Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic sulfur compound shown to act against tumor cells. Tamoxifen is a commercially av...

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Publicat a:BMC Cancer
Autors principals: SP, Nipin, Darvin, Pramod, Yoo, Young Beom, Joung, Youn Hee, Kang, Dong Young, Kim, Don Nam, Hwang, Tae Sook, Kim, Sang Yoon, Kim, Wan Seop, Lee, Hak Kyo, Cho, Byung Wook, Kim, Heui Soo, Park, Kyung Do, Park, Jong Hwan, Chang, Soung Hoon, Yang, Young Mok
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472404/
https://ncbi.nlm.nih.gov/pubmed/26084564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1445-0
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