The microRNA-132 and microRNA-212 cluster regulates hematopoietic stem cell maintenance and survival with age by buffering FOXO3 expression

MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though little remains known about their role in aging hematopoietic stem cells (HSCs). We found that the microRNA-212/132 cluster (Mirc19) is enriched in HSCs and is up-regulated during aging. Both over-expr...

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Veröffentlicht in:Immunity
Hauptverfasser: Mehta, Arnav, Zhao, Jimmy L., Sinha, Nikita, Marinov, Georgi K., Mann, Mati, Kowalczyk, Monika S., Galimidi, Rachel P., Du, Xiaomi, Erikci, Erdem, Regev, Aviv, Chowdhury, Kamal, Baltimore, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471877/
https://ncbi.nlm.nih.gov/pubmed/26084022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.05.017
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