Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages. By analyzing clonal imprints on the walls...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Baker, Ann-Marie, Cereser, Biancastella, Melton, Samuel, Fletcher, Alexander G., Rodriguez-Justo, Manuel, Tadrous, Paul J., Humphries, Adam, Elia, George, McDonald, Stuart A.C., Wright, Nicholas A., Simons, Benjamin D., Jansen, Marnix, Graham, Trevor A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471679/
https://ncbi.nlm.nih.gov/pubmed/25127143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.019
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