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Combinatorial Library Based Engineering of Candida antarctica Lipase A for Enantioselective Transacylation of sec-Alcohols in Organic Solvent**
A method for determining lipase enantioselectivity in the transacylation of sec-alcohols in organic solvent was developed. The method was applied to a model library of Candida antarctica lipase A (CalA) variants for improved enantioselectivity (E values) in the kinetic resolution of 1-phenylethanol...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
WILEY-VCH Verlag
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4471580/ https://ncbi.nlm.nih.gov/pubmed/25676632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201410675 |
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