UvrD facilitates DNA repair by pulling RNA polymerase backwards

UvrD helicase is required for nucleotide excision repair, although its role in this process is not well defined. Here we show that Escherichia coli UvrD binds RNA polymerase during transcription elongation and, using its helicase/translocase activity, forces RNA polymerase to slide backward along DN...

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Vydáno v:Nature
Hlavní autoři: Epshtein, Vitaly, Kamarthapu, Venu, McGary, Katelyn, Svetlov, Vladimir, Ueberheide, Beatrix, Proshkin, Sergey, Mironov, Alexander, Nudler, Evgeny
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471481/
https://ncbi.nlm.nih.gov/pubmed/24402227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12928
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