A Short-term In Vivo Screen Using Fetal Testosterone Production, a Key Event in the Phthalate Adverse Outcome Pathway, to Predict Disruption of Sexual Differentiation

This study was designed to develop and validate a short-term in vivo protocol termed the Fetal Phthalate Screen (FPS) to detect phthalate esters (PEs) and other chemicals that disrupt fetal testosterone synthesis and testis gene expression in rats. We propose that the FPS can be used to screen chemi...

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Sci
Hauptverfasser: Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., Foster, Paul M., Gray, Leon E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Reproductive and Developmental Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471440/
https://ncbi.nlm.nih.gov/pubmed/24798384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu081
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