AMPA Receptor–mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role

Sarcosine, an endogenous amino acid, is a competitive inhibitor of the type I glycine transporter and an N-methyl-d-aspartate receptor (NMDAR) coagonist. Recently, we found that sarcosine, an NMDAR enhancer, can improve depression-related behaviors in rodents and humans. This result differs from pre...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Chen, Kuang-Ti, Tsai, Mang-Hung, Wu, Ching-Hsiang, Jou, Ming-Jia, Wei, I-Hua, Huang, Chih-Chia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471371/
https://ncbi.nlm.nih.gov/pubmed/26150775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00162
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