Efficacy of Lapatinib in Therapy-Resistant HER2-Positive Circulating Tumor Cells in Metastatic Breast Cancer

BACKGROUND: To evaluate the efficacy of lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, in therapy-resistant HER2-positive CTCs in metastatic breast cancer (MBC). PATIENTS AND METHODS: Patients with MBC and HER2-positive CTCs despite disease stabilization or response to prior therapy, rec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Agelaki, Sofia, Kalykaki, Antonia, Markomanolaki, Harris, Papadaki, Maria A., Kallergi, Galatea, Hatzidaki, Dora, Kalbakis, Kostas, Mavroudis, Dimitrios, Georgoulias, Vassilis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471111/
https://ncbi.nlm.nih.gov/pubmed/26083256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123683
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