Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2)

In this work, we evaluated the cytotoxicity of mesoionic 4-phenyl-5-(2-Y, 4-X or 4-X-cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivatives (MI-J: X=OH, Y=H; MI-D: X=NO(2), Y=H; MI-4F: X=F, Y=H; MI-2,4diF: X=Y=F) on human hepatocellular carcinoma (HepG2), and non-tumor cells (rat hepatocy...

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Udgivet i:PLoS One
Main Authors: Gozzi, Gustavo Jabor, Pires, Amanda do Rocio Andrade, Valdameri, Glaucio, Rocha, Maria Eliane Merlin, Martinez, Glaucia Regina, Noleto, Guilhermina Rodrigues, Acco, Alexandra, Alves de Souza, Carlos Eduardo, Echevarria, Aurea, Moretto dos Reis, Camilla, Di Pietro, Attilio, Suter Correia Cadena, Sílvia Maria
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470815/
https://ncbi.nlm.nih.gov/pubmed/26083249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130046
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