Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2)

In this work, we evaluated the cytotoxicity of mesoionic 4-phenyl-5-(2-Y, 4-X or 4-X-cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivatives (MI-J: X=OH, Y=H; MI-D: X=NO(2), Y=H; MI-4F: X=F, Y=H; MI-2,4diF: X=Y=F) on human hepatocellular carcinoma (HepG2), and non-tumor cells (rat hepatocy...

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Publicado en:PLoS One
Autores principales: Gozzi, Gustavo Jabor, Pires, Amanda do Rocio Andrade, Valdameri, Glaucio, Rocha, Maria Eliane Merlin, Martinez, Glaucia Regina, Noleto, Guilhermina Rodrigues, Acco, Alexandra, Alves de Souza, Carlos Eduardo, Echevarria, Aurea, Moretto dos Reis, Camilla, Di Pietro, Attilio, Suter Correia Cadena, Sílvia Maria
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470815/
https://ncbi.nlm.nih.gov/pubmed/26083249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130046
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