Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus

Hypertension (HTN) resulting from subcutaneous infusion of ANG II and dietary high salt (HS) intake involves sympathoexcitation. Recently, we reported reduced small-conductance Ca(2+)-activated K(+) (SK) current and increased excitability of presympathetic neurons in the paraventricular nucleus (PVN...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Larson, Robert A., Gui, Le, Huber, Michael J., Chapp, Andrew D., Zhu, Jianhua, LaGrange, Lila P., Shan, Zhiying, Chen, Qing-Hui
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
Fag:
Cardiovascular Neurohormonal Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469880/
https://ncbi.nlm.nih.gov/pubmed/25862832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00832.2014
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