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Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related cardiac inflammation, we studied six groups of mice: young (3–5 mo old), middle-aged (10–12 mo old), and old (18–29 mo old) C57BL/6 wild-type (WT) and SPARC-null (Null) mice (n = 7–10/group). Cardiac funct...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Toba, Hiroe, de Castro Brás, Lisandra E., Baicu, Catalin F., Zile, Michael R., Lindsey, Merry L., Bradshaw, Amy D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469747/
https://ncbi.nlm.nih.gov/pubmed/25877699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00402.2014
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