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Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism

Selective estrogen receptor modulators (SERM) including tamoxifen are known to inhibit angiogenesis. However, the underlying mechanism, which is independent of their action on the estrogen receptor (ER), has remained largely unknown. In the present study, we found that tamoxifen and other SERM inhib...

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Detalles Bibliográficos
Publicado en:Cancer Lett
Main Authors: Shim, Joong Sup, Li, Ruo-Jing, Lv, Junfang, Head, Sarah, Yang, Eun Ju, Liu, Jun O.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469646/
https://ncbi.nlm.nih.gov/pubmed/25799952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.03.022
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