Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these...

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Publié dans:PLoS Med
Auteurs principaux: Østergaard, Søren D., Mukherjee, Shubhabrata, Sharp, Stephen J., Proitsi, Petroula, Lotta, Luca A., Day, Felix, Perry, John R. B., Boehme, Kevin L., Walter, Stefan, Kauwe, John S., Gibbons, Laura E., Larson, Eric B., Powell, John F., Langenberg, Claudia, Crane, Paul K., Wareham, Nicholas J., Scott, Robert A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469461/
https://ncbi.nlm.nih.gov/pubmed/26079503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001841
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