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Effective heritable gene knockdown in zebrafish using synthetic microRNAs
Although zebrafish is used to model human diseases through mutational and morpholino-based knockdown approaches, there are currently no robust transgenic knockdown tools. Here we investigate the knockdown efficiency of three synthetic miRNA-expressing backbones and show that these constructs can dow...
Sparad:
| I publikationen: | Nat Commun |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Pub. Group
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468906/ https://ncbi.nlm.nih.gov/pubmed/26051838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8378 |
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