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Can Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?
Natural killer (NK) cells express inhibiting receptors (iNKRs), which specifically bind MHC-I molecules on the surface of healthy cells. When the expression of MHC-I on the cell surface decreases, which might occur during certain viral infections and cancer, iNKRs lose inhibiting signals and the inf...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468891/ https://ncbi.nlm.nih.gov/pubmed/26136746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00311 |
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