Genetic and Clinical Factors Affecting Plasma Clozapine Concentration

Objective: To assess (1) the variance of plasma clozapine levels; (2) the relative importance of sex, smoking habits, weight, age, and specific genetic variants of cytochrome P450 1A2 (CYP1A2), uridine diphosphate glucuronosyltransferase 1A4 (UGT1A4), and multidrug resistance protein 1 (MDR1) on pla...

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Veröffentlicht in:Prim Care Companion CNS Disord
Hauptverfasser: Olsson, Eric, Edman, Gunnar, Bertilsson, Leif, Hukic, Dzana Sudic, Lavebratt, Catharina, Eriksson, Sven V., Ösby, Urban
Format: Artigo
Sprache:Inglês
Veröffentlicht: Physicians Postgraduate Press, Inc. 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468884/
https://ncbi.nlm.nih.gov/pubmed/26137357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/PCC.14m01704
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