Fluconazole Population Pharmacokinetics and Dosing for Prevention and Treatment of Invasive Candidiasis in Children Supported with Extracorporeal Membrane Oxygenation

Candida infections are a leading cause of infectious disease-related death in children supported by extracorporeal membrane oxygenation (ECMO). The ECMO circuit can alter drug pharmacokinetics (PK); thus, standard fluconazole dosing may result in suboptimal drug exposures. The objective of our study...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Watt, Kevin M., Gonzalez, Daniel, Benjamin, Daniel K., Brouwer, Kim L. R., Wade, Kelly C., Capparelli, Edmund, Barrett, Jeffrey, Cohen-Wolkowiez, Michael
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468733/
https://ncbi.nlm.nih.gov/pubmed/25896706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00102-15
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