Pharmacokinetic Interactions between BMS-626529, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug BMS-663068, and Ritonavir or Ritonavir-Boosted Atazanavir in Healthy Subjects

BMS-663068 is a prodrug of BMS-626529, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4(+) T cells. This open-label, multiple-dose, four-sequence, crossover study addressed potential two-way drug-drug interactions f...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Zhu, Li, Hruska, Matthew, Hwang, Carey, Shah, Vaishali, Furlong, Michael, Hanna, George J., Bertz, Richard, Savant Landry, Ishani
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468697/
https://ncbi.nlm.nih.gov/pubmed/25870057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04914-14
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